Assessment of sclerostin levels in the gingival crevicular fluid of patients with periodontitis: A clinico-biochemical crosssectional study

Background. Sclerostin, a glycoprotein, plays key role in regulating bone mass. In this study, sclerostin levels the gingival crevicular fluid (GCF) were assessed patients with Stage III Grade C generalized periodontitis (SIII-GC) and B (SIII-GB). Methods. This cross-sectional study included 30 participants divided equally into three groups: group I (gingival health), II (SIII-GC), Clinical periodontal parameters like plaque index (PI), bleeding (GBI), probing pocket depth (PD), clinical attachment level (CAL) recorded. A sandwich ELISA was used to determine GCF samples. One-way ANOVA post hoc Tukey tests analyze levels. The association between using Pearson’s correlation coefficient (r). Results. Patients groups had much higher their than (P≤0.05). contrast, no significant difference observed two diseased conditions (P=0.841). Concerning parameters, statistically groups. There positive expression of Conclusion. Increased indicated that it could be considered reliable biomarker disease activity.